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QUELICIN® (succinylcholine chloride injection, USP) Description

DESCRIPTION

QUELICIN (Succinylcholine Chloride Injection, USP) is a sterile, nonpyrogenic solution to be used as an ultra short-acting, depolarizing, skeletal muscle relaxant See HOW SUPPLIED for summary of content and characteristics of the solutions. The solutions are for intramuscular (IM) or intravenous (IV) use.

Succinylcholine Chloride, USP is chemically designated C14H30Cl2N2O4 and its molecular weight is 361.31.

It has the following structural formula:

structural formula succinylcholine chloride

Succinylcholine is a diquaternary base consisting of the dichloride salt of the dicholine ester of succinic acid. It is a white, odorless, slightly bitter powder, very soluble in water. The drug is incompatible with alkaline solutions but relatively stable in acid solutions. Solutions of the drug lose potency unless refrigerated.

Solution intended for multiple-dose administration contains 0.18% methylparaben and 0.02% propylparaben as preservatives (List No. 6629). Solution intended for single-dose administration contains no preservatives. Unused solution should be discarded. Product not requiring dilution (multiple-dose fliptop vial) contains sodium chloride to render isotonic. May contain sodium hydroxide and/or hydrochloric acid for pH adjustment. pH is 3.6 (3.0 to 4.5). The 100 mg/mL solution has an osmolarity of 0.830 mOsml/mL (calc.) and the 20 mg/mL solution has an osmolarity of 0.338 mOsml/mL (calc.).

Sodium Chloride, USP, chemically designated NaCl, is a white crystalline compound freely soluble in water.

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